Formanilide, 2-chloro-
N-(2-CHLORO-PHENYL)-FORMAMIDE
CAS: 2596-93-2
Molecular Formula: C7H6ClNO
Formanilide, 2-chloro- - Names and Identifiers
Formanilide, 2-chloro- - Physico-chemical Properties
| Molecular Formula | C7H6ClNO |
| Molar Mass | 155.58 |
| Density | 1.316±0.06 g/cm3(Predicted) |
| Melting Point | 76-80 °C(lit.) |
| Boling Point | 316.2±25.0 °C(Predicted) |
| pKa | 14.07±0.70(Predicted) |
Formanilide, 2-chloro- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
Formanilide, 2-chloro- - Upstream Downstream Industry
| Downstream Products | 2-CHLOROANILINE HYDROCHLORIDE |
Formanilide, 2-chloro- - Introduction
N-(2-chroo-phenyl)-FORMAMIDE is an organic compound with the chemical formula C7H6ClNO. It is a colorless crystalline solid, soluble in organic solvents. The following is a description of the properties, uses, formulation and safety information of N-(2-chroo-phenyl)-FORMAMIDE:
Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 157.58g/mol
-Solubility: Soluble in ethanol, ether and dichloromethane, insoluble in water
-Melting Point: 67-69 ℃
-Boiling point: 265 ℃
Use:
N-(2-chroo-phenyl)-FORMAMIDE has certain application value in organic synthesis. It can be used as an intermediate in organic synthesis, and is often used in the synthesis of Benzazepine fused rings (such as flurane, benzperamine, etc.) and pesticides in drug synthesis. In addition, it can also be used in dyes, coatings and medical fields.
Method:
The preparation of N-(2-CHLORO-PHENYL)-FORMAMIDE can be obtained by the reaction of benzamide with thionyl chloride. Specific methods are as follows:
1. Take benzamide and sulfoxide according to the material ratio of 1:1 added to dry thionyl chloride.
2. Heat the reaction mixture and react at 150-160°C for 6-8 hours.
3. After completion of the reaction, the mixture was cooled to room temperature.
4. The reaction mixture was filtered and the solid product was collected.
5. Pure N-(2-chloroo-phenyl)-FORMAMIDE is obtained by recrystallization and drying.
Safety Information:
N-(2-chroo-phenyl)-FORMAMIDE needs to be handled carefully, and appropriate protective measures should be taken when using it, such as wearing chemical protective gloves and goggles, ensure that the operation is carried out in a well-ventilated environment. Avoid contact with skin, eyes and respiratory tract. If you come into contact with this substance, rinse immediately with plenty of water and seek medical treatment. In addition, it should be stored in a sealed container, avoiding contact with air and moisture.
Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 157.58g/mol
-Solubility: Soluble in ethanol, ether and dichloromethane, insoluble in water
-Melting Point: 67-69 ℃
-Boiling point: 265 ℃
Use:
N-(2-chroo-phenyl)-FORMAMIDE has certain application value in organic synthesis. It can be used as an intermediate in organic synthesis, and is often used in the synthesis of Benzazepine fused rings (such as flurane, benzperamine, etc.) and pesticides in drug synthesis. In addition, it can also be used in dyes, coatings and medical fields.
Method:
The preparation of N-(2-CHLORO-PHENYL)-FORMAMIDE can be obtained by the reaction of benzamide with thionyl chloride. Specific methods are as follows:
1. Take benzamide and sulfoxide according to the material ratio of 1:1 added to dry thionyl chloride.
2. Heat the reaction mixture and react at 150-160°C for 6-8 hours.
3. After completion of the reaction, the mixture was cooled to room temperature.
4. The reaction mixture was filtered and the solid product was collected.
5. Pure N-(2-chloroo-phenyl)-FORMAMIDE is obtained by recrystallization and drying.
Safety Information:
N-(2-chroo-phenyl)-FORMAMIDE needs to be handled carefully, and appropriate protective measures should be taken when using it, such as wearing chemical protective gloves and goggles, ensure that the operation is carried out in a well-ventilated environment. Avoid contact with skin, eyes and respiratory tract. If you come into contact with this substance, rinse immediately with plenty of water and seek medical treatment. In addition, it should be stored in a sealed container, avoiding contact with air and moisture.
Last Update：2024-04-09 20:52:54
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